Our science is rooted in our profound understanding of muscle stem cell biology, tissue regeneration and mitochondria function in rejuvenating muscle. Epirium’s small molecule inhibitors target an endogenous pathway that is induced following muscle injury and coordinates the injury repair process and ensures effective regeneration of functional muscle. Our lead candidates utilize the body’s own natural biological repair processes to repair and restore tissues, thus slowing down the progressive degenerative processes that underlie a wide range of musclerelated diseases. We believe our unique mechanism of action and novel small molecules have potential for broad clinical applicability across a number of therapeutic areas

Scientific Foundation:

PGE2 Signaling Critical for Muscle Maintenance, Repair and Rejuvenation

PGE2 Augments
Muscle Stem Cell function
Muscle fiber function

Muscle Stem Cell function

  • Essential signaling molecule for muscle regeneration
  • Required for muscle stem cell expansion and engraftment
Muscle fiber function

  • Novel hallmark of aged muscles 15-PGDH degradation of PGE2
  • One month of treatment in aged mice produced stat sig. increase in muscle strength, meaningful improvement in endurance*
  • Physiologic modulation of PGE2 levels has meaningful benefit in muscle fiber differentiation and function 


Mechanism of Action Increasing PGE2

Through Inhibition of 15-PGDH, the metabolizing enzyme of PGE2

Normal Muscle

Palla et al. Science, 2021

Sarcopenic Muscle

Treated Sarcopenic
Muscle +PGE2