Our science is rooted in our profound understanding of muscle stem cell biology, tissue regeneration and mitochondria function in rejuvenating muscle. Epirium’s small molecule inhibitors target an endogenous pathway that is induced following muscle injury and coordinates the injury repair process and ensures effective regeneration of functional muscle. Our lead candidates utilize the body’s own natural biological repair processes to repair and restore tissues, thus slowing down the progressive degenerative processes that underlie a wide range of muscle–related diseases. We believe our unique mechanism of action and novel small molecules have potential for broad clinical applicability across a number of therapeutic areas
Scientific Foundation:
PGE2 Signaling Critical for Muscle Maintenance, Repair and Rejuvenation
- Essential signaling molecule for muscle regeneration
- Required for muscle stem cell expansion and engraftment
-
Novel hallmark of aged muscles 15-PGDH degradation of PGE2
-
One month of treatment in aged mice produced stat sig. increase in muscle strength, meaningful improvement in endurance*
-
Physiologic modulation of PGE2 levels has meaningful benefit in muscle fiber differentiation and function
Mechanism of Action Increasing PGE2
Through Inhibition of 15-PGDH, the metabolizing enzyme of PGE2
Normal Muscle
+PGE2
Palla et al. Science, 2021
Sarcopenic Muscle
-PGE2
Treated Sarcopenic
Muscle +PGE2
