Our science is rooted in our profound understanding of muscle stem cell biology, tissue regeneration and mitochondria function in rejuvenating muscle. Epirium’s small molecule inhibitors target an endogenous pathway that is induced following muscle injury and coordinates the injury repair process and ensures effective regeneration of functional muscle. Our lead candidates utilize the body’s own natural biological repair processes to repair and restore tissues, thus slowing down the progressive degenerative processes that underlie a wide range of muscle–related diseases. We believe our unique mechanism of action and novel small molecules have potential for broad clinical applicability across a number of therapeutic areas
Mechanism of Action Increasing PGE2
Through Inhibition of 15-PGDH, the metabolizing enzyme of PGE2
Normal Muscle
+PGE2
Palla et al. Science, 2021
Sarcopenic Muscle
-PGE2
Treated Sarcopenic
Muscle +PGE2
